Hydrogen Bromide → HCID 86598444, compound

HRID 2247393Notes

Reaction equation

HRID 2247393 reaction equation
Br.FC1C=CC(C2[S:13][C:12]([NH:14]C(=O)C)=[N:11]C=2C)=CC=1OC.Br[CH:22]([C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([S:33]([N:36]2[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]2)(=[O:35])=[O:34])[CH:27]=1)[C:23](=O)[CH3:24].C(NC(N)=S)(=O)C.NC(N)=S>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([C:22]2[S:13][C:12]([NH2:14])=[N:11][C:23]=2[CH3:24])=[CH:27][C:28]=1[S:33]([N:36]1[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]1)(=[O:35])=[O:34]

Participants

6

Reactant 5

HCID 260Hydrogen BromideHCID 2723593AcetylthioureaHCID 2723790ThioureaHCID 85861692HCID 85861692, compoundHCID 86761072HCID 86761072, compound

Product 1

HCID 86598444HCID 86598444, compound

Procedure

The title compound is prepared as an HBr salt by the same procedure as N-[5-(4-fluoro-3-methoxy-phenyl)-4-methyl-thiazol-2-yl]-acetamide (161c) by replacing 1-bromo-1-(4-fluoro-3-methoxy-phenyl)-propan-2-one (161b) with 1-bromo-1-[4-chloro-3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-propan-2-one (171c) and N-acetylthiourea with thiourea.

Sources & evidence

ORD record
ord-3bc463143aae4c83adc19ad50cd78f9f
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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