Hydrochloric Acid → ((3S)-1-(3,4-difluorobenzyl)pyrrolidine-3-yl)amine dihydrochloride

HRID 2247523Notes

Reaction equation

HRID 2247523 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)[CH2:9]1)(C)(C)C.[ClH:23]>C(OCC)(=O)C>[ClH:23].[ClH:23].[F:21][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[F:20])[CH2:13][N:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66961515(3S)-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)carbamic acid tert-butyl ester

Product 1

HCID 66960173((3S)-1-(3,4-difluorobenzyl)pyrrolidine-3-yl)amine dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To an ethyl acetate solution (5 mL) of (3S)-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)carbamic acid tert-butyl ester (1.55 g), an ethyl acetate (5 mL) solution of 4N hydrochloric acid was added, and the reaction solution was agitated at room temperature. Deposited substances in the reaction solution was separated by filtering after 10 hours, and 904 mg of the title compound was obtained by further washing with ether. The physical properties of the compound are as follows.

Workup

  1. customDeposited substances in the reaction solution was separated
  2. filtrationby filtering after 10 hours

Sources & evidence

ORD record
ord-7d6a680beeb141478052862482e5b462
Source dataset
uspto-grants-2010_03
Patent number
US07687640B2

Reaction notes

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