Ethanol → HCID 86602485, compound

HRID 2247560Notes

Reaction equation

HRID 2247560 reaction equation
C(O)C.[N:4]1([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[C:15](=O)[CH2:14][CH2:13]3)[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1.[Cl-].[OH:21][NH3+:22].C(N(CC)CC)C>C(OCC)(=O)C.O>[N:4]1([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[C:15](=[N:22][OH:21])[CH2:14][CH2:13]3)[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1

Participants

7

Reactant 4

HCID 702EthanolHCID 8471TriethylamineHCID 21645Hydroxylamine HClHCID 461728755-(Morpholin-4-yl)-2,3-dihydro-1H-inden-1-one

Product 1

HCID 86602485HCID 86602485, compoundYield 96.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

An ethanol (5.0 mL) solution of 5-morpholin-4-yl-indan-1-one (2.20 g), hydroxyl ammonium chloride (1.05 g) and the triethylamine (4.22 mL) was refluxed for 3 hours. Water and ethyl acetate were added to the reaction solution, and the organic layer was partitioned. The obtained organic layer was washed with a saturated sodium chloride solution, and 2.28 g of the title compound was obtained by condensing under reduce pressure after drying over anhydrous magnesium sulfate. The physical properties of the compound are as follows.

Workup

  1. customthe organic layer was partitioned
  2. washThe obtained organic layer was washed with a saturated sodium chloride solution

Sources & evidence

ORD record
ord-02ff8821132e4e369cea392b9c19181b
Source dataset
uspto-grants-2010_03
Patent number
US07687640B2

Reaction notes

Loading…