Potassium Iodide → HCID 23330429, compound

HRID 224768Notes

Reaction equation

HRID 224768 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6](=[O:12])[CH2:5]2.[Br:13][CH2:14][CH2:15][CH2:16]Br.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(Cl)Cl.C(C(C)=O)C>[Br:13][CH2:14][CH2:15][CH2:16][O:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6](=[O:12])[CH2:5]2

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 100578412H-Indol-2-one, 1,3-dihydro-5-hydroxy-1-methyl-

Product 1

HCID 23330429HCID 23330429, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 11.9 g of 5-hydroxy-1-methyl-2-indolinone, 29.2 g of 1,3-dibromopropane, 11 g of potassium carbonate, 1 g of potassium iodide and 75 ml of ethylmethyl ketone is refluxed for 20 hours. The mixture is then diluted with 300 ml of methylene dichloride, washed with water and the solvent is removed under reduced pressure.

Workup

  1. temperatureis refluxed for 20 hours
  2. washwashed with water
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-c9c7bfd9925240e0b478bb04c86a7316
Source dataset
uspto-grants-1980_11
Patent number
US04234584

Reaction notes

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