Guaiacol → 4-(2-Methoxyphenoxy)benzoic acid

HRID 2247731Notes

Reaction equation

HRID 2247731 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[OH:18].C(=O)([O-])[O-:20].[K+].[K+].CC(=CC)C.P([O-])(O)(O)=O.[K+].Cl[O-].[Na+]>>[CH3:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][C:2]1[CH:9]=[CH:8][C:5]([C:6]([OH:20])=[O:7])=[CH:4][CH:3]=1

Participants

7

Reactant 6

HCID 460GuaiacolHCID 105532-Methyl-2-buteneHCID 11430Potassium CarbonateHCID 680234-FluorobenzaldehydeHCID 516951Monobasic potassium phosphateHCID 23665760Sodium Hypochlorite

Product 1

HCID 6184504-(2-Methoxyphenoxy)benzoic acidYield 89%

Procedure

The title compound (1.6 g) was synthesized in a yield of 89% as a yellowish white crystalline solid by conducting the similar reaction to that mentioned in Example 10 (10e) using 4-fluorobenzaldehyde (1.2 g, 10 mmol), 2-methoxyphenol (1.7 g, 14 mmol), potassium carbonate (3.5 g, 25 mmol), 2-methyl-2-butene (3.9 ml, 37 mmol), potassium dihydrogenphosphate (2.5 g, 19 mmol) and sodium hypochlorite (2.0 g, 22 mmol).

Workup

  1. customthe similar reaction to

Sources & evidence

ORD record
ord-191b3731ebbe4a64a6f76ef9c236ac6d
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

Loading…