1-[(4-Chlorophenyl)methyl]-4-(3-chloropropyl)piperazine → Hydrochloric Acid

HRID 224774Notes

Reaction equation

HRID 224774 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:12])=[CH:9][CH:10]=2)[C:5]([CH3:13])=[CH:4][C:3]1=[O:14].[Cl:15][C:16]1[CH:32]=[CH:31][C:19]([CH2:20][N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29]Cl)[CH2:23][CH2:22]2)=[CH:18][CH:17]=1>>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH2:29][CH2:28][CH2:27][N:24]3[CH2:25][CH2:26][N:21]([CH2:20][C:19]4[CH:18]=[CH:17][C:16]([Cl:15])=[CH:32][CH:31]=4)[CH2:22][CH2:23]3)=[CH:9][CH:10]=2)[C:5]([CH3:13])=[CH:4][C:3]1=[O:14].[ClH:15]

Participants

4

Reactant 2

HCID 133997271-[(4-Chlorophenyl)methyl]-4-(3-chloropropyl)piperazineHCID 20473344HCID 20473344, compound

Product 2

HCID 313Hydrochloric AcidHCID 23330443HCID 23330443, compound

Procedure

1,4-Dimethyl-6-hydroxy-2-oxo-1,2-dihydroquinoline is reacted with 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propyl chloride in a manner analogous to that described in Example 3. There is obtained 1,4-dimethyl-6-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline in the form of a hydrochloride which melts, with decomposition, at 215°-220° C.

Sources & evidence

ORD record
ord-8be43f7b887f4fe1a36aa1ac1ec680e9
Source dataset
uspto-grants-1980_11
Patent number
US04234585

Reaction notes

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