4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene → HCID 22076497, compound

HRID 2247786Notes

Reaction equation

HRID 2247786 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[NH2:15][CH2:16][CH:17]([OH:20])[CH2:18][OH:19]>>[OH:20][CH:17]([CH2:18][OH:19])[CH2:16][NH:15][C:4]1[C:3]([N+:12]([O-:14])=[O:13])=[CH:2][CH:7]=[CH:6][C:5]=1[C:8]([F:11])([F:10])[F:9]

Participants

3

Reactant 2

HCID 84624-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotolueneHCID 735613-Amino-1,2-propanediol

Product 1

HCID 22076497HCID 22076497, compound

Procedure

23 g (0.10 moles) 4-chloro-3-nitro-1-trifluoromethyl-benzene are heated with 30 g 1-amino-2,3-propandiol for 3 hours to 100° C. After cooling, the product is precipitated with water, vacuumed off and dried. One obtains 26.7 g (93% of the theoretical yield) of a yellow product with a melting range of 117°-118 C.

Workup

  1. temperatureAfter cooling
  2. customthe product is precipitated with water
  3. customdried
  4. customOne obtains 26.7 g (93% of the
  5. customtheoretical yield) of a yellow product with a melting range of 117°-118 C

Sources & evidence

ORD record
ord-b8c2973d747a4632bf2fa0fa22aefb9f
Source dataset
uspto-grants-1991_08
Patent number
US05037446

Reaction notes

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