Hydrochloric Acid → HCID 178512798, compound

HRID 2247815Notes

Reaction equation

HRID 2247815 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[NH2:13][C:14]([NH2:16])=[NH:15].Cl>O1CCOCC1>[NH:15]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:14]([NH2:16])=[NH:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3520GuanidineHCID 5482219-Bromononanoic Acid

Product 1

HCID 178512798HCID 178512798, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

9-Bromo-nonanoic acid (5 gm; 21.1 mmoles) was dissolved in dioxane (50 ml) and the free guanidine solution from B was added. The mixture was refluxed overnight, and the white precipitate was filtered and washed three times with cold water and then lyophilized from one equivalent of 0.5 M HCl. The yield was 2.77g (85%) and the structure of the title compound was verified by FAB-MS, NMR, and elemental analysis.

Workup

  1. temperatureThe mixture was refluxed overnight
  2. filtrationthe white precipitate was filtered
  3. washwashed three times with cold water

Sources & evidence

ORD record
ord-10b47b97d8bb408dab761bd65cd516b6
Source dataset
uspto-grants-1991_08
Patent number
US05037808

Reaction notes

Loading…