SK&F 45349 → HCID 54417837, compound

HRID 2247865Notes

Reaction equation

HRID 2247865 reaction equation
[C:1]([C:3]1[S:4][C:5]([CH:8]=O)=[CH:6][CH:7]=1)#[N:2].[C:10]([CH:18]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCCC1>[C:1]([C:3]1[S:4][C:5]([CH:8]=[CH:18][C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:17])=[CH:6][CH:7]=1)#[N:2]

Participants

4

Reactant 2

HCID 70073SK&F 45349HCID 122800045-Formylthiophene-2-Carbonitrile

Product 1

HCID 54417837HCID 54417837, compoundYield 56.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2-cyano-5-formylthiophene (4 g) and benzoylmethylenetriphenylphosphorane (11.09 g) in tetrahydrofuran (40 ml) was refluxed for 30 minutes. The reaction mixture was evaporated in vacuo to give 3-(5-cyano-2-thienyl)-1-phenyl-2-propen-1-one (3.95 g).

Workup

  1. temperaturewas refluxed for 30 minutes
  2. customThe reaction mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-44df1a27d69f4d52a86eab8cd1706fd8
Source dataset
uspto-grants-1991_08
Patent number
US05037824

Reaction notes

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