Hydrochloric Acid → HCID 19815932, compound

HRID 2247872Notes

Reaction equation

HRID 2247872 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)=[CH:8][C:9]([C:13]([OH:15])=O)=[N:10][C:11]=1[CH3:12])=[O:5])[CH3:2].[O:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][NH2:33])[CH2:27][CH2:26]1.[ClH:34]>C(O)C>[ClH:34].[ClH:34].[CH3:12][C:11]1[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=2)[CH:8]=[C:9]([C:13](=[O:15])[NH:33][CH2:32][CH2:31][N:28]2[CH2:29][CH2:30][O:25][CH2:26][CH2:27]2)[N:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4082852-MorpholinoethylamineHCID 10246038HCID 10246038, compound

Product 1

HCID 19815932HCID 19815932, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-methyl-6-(2-morpholinoethylcarbamoyl)-4-(3-nitrophenyl)-3-pyridinecarboxylate, which was obtained according to a similar manner to that of Example 11 from 5-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-2--pyridinecarboxylic acid (1.3 g) and 2-morpholinoethylamine (1.28 g), was treated with a solution of hydrogen chloride in ethanol to give ethyl 2-methyl-6-(2-morpholinoethylcarbamoyl)-4-(3-nitrophenyl)-3-pyridinecarboxylate dihydrochloride (1.2 g).

Sources & evidence

ORD record
ord-5b521417b96245cc9a169d123b126534
Source dataset
uspto-grants-1991_08
Patent number
US05037824

Reaction notes

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