Hydrogen Bromide → HCID 136037530, compound

HRID 2247897Notes

Reaction equation

HRID 2247897 reaction equation
O[CH:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][NH:7][C:6]2=[O:13].[BrH:20]>C(O)(=O)C>[BrH:20].[Br:20][CH:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][NH:7][C:6]2=[O:13]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 135800570757238-43-0

Product 1

HCID 136037530HCID 136037530, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4 parts of intermediate 38, namely 6-(hydroxyphenylmethyl)-4(3H)-quinazolinone, and 67.7 parts of a solution of hydrobromic acid in acetic acid 30% was stirred for 24 hours at room temperature. The reaction mixture was evaporated and the residue was co-evaporated with methylbenzene, yielding 6.5 parts (100%) of 6-(bromophenylmethyl)-4(3H)-quinazolinone monohydrobromide (interm. 48).

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-8889431b586845bebf08e7c757a1f8b3
Source dataset
uspto-grants-1991_08
Patent number
US05037829

Reaction notes

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