反应详情

To a suspension of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide (0.5 g) in trifluoroacetic acid (15 ml) at -10° was added borane-tetrahydrofuran complex (45 ml; 1M) keeping the temperature below +2°. The resulting suspension was stirred at 0° for 5 min, poured onto saturated potassium carbonate (50 ml) and extracted with ethanol (2×20 ml). The ethanolic extract was evaporated and the residue purified by column chromatography (A) to give the title compound as an oil (80 mg). T.l.c. (N), Rf 0.53 (IPA, CeIV).

1. additionwas added borane-tetrahydrofuran complex (45 ml; 1M)
2. customthe temperature below +2°
3. extractionextracted with ethanol (2×20 ml)
4. extractionThe ethanolic extract
5. customwas evaporated
6. customthe residue purified by column chromatography (A)