反应详情

To a solution of methyl-2-benzylacrylate (20 gm. 0.113 mol) in methanol (100 ml) at room temperature was added a solution of sodium methoxide (2N, 17 ml) followed by isopropylthiol (12.56 ml). TLC (4:1, Hexanes: ethyl acetate) showed reaction to be complete after 30 min. The reaction mixture was made acidic with 1N HCl and extracted three times with ethyl acetate. The combined organic fractions were dried over NaSO4, filtered and evaporated in vacuo. The crude product was purified by chromatography (silica 4:1, hexanes: ethyl acetate to give methyl-3-isopropylthio-2-benzylpropionate.

1. customreaction
2. extractionextracted three times with ethyl acetate
3. dry with materialThe combined organic fractions were dried over NaSO4
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe crude product was purified by chromatography (silica 4:1, hexanes