反应详情

A mixture of 25 parts of 4-fluoro-3-nitro-α-phenylbenzenemethanol, 20 parts of hydrazine monohydrate and 80 parts of ethanol was stirred for 1.5 hours at reflux temperature. After cooling, 20 parts of a hydrochloric acid solution 10N were added. After concentration, the residue was washed twice with 50 parts of water and dissolved in a solution of 300 parts methanol (10%) in trichloromethane. The organic layer was dried, filtered and concentrated, yielding 23.8 parts (98.6%) of 1-hydroxy-α-phenyl-1H-benzotriazole-6-methanol as a residue (int. 64).

1. temperatureat reflux temperature
2. temperatureAfter cooling
3. concentrationAfter concentration
4. washthe residue was washed twice with 50 parts of water
5. dissolutiondissolved in a solution of 300 parts methanol (10%) in trichloromethane
6. customThe organic layer was dried
7. filtrationfiltered
8. concentrationconcentrated