Dimethylformamide → HCID 14988296, compound

HRID 2248475Notes

Reaction equation

HRID 2248475 reaction equation
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)#[N:2].[OH-].[K+].C[N:16](C)C=O>>[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([NH2:16])[CH:5]=1)#[N:2]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 14797Potassium HydroxideHCID 351795Indole-3-acetonitrile

Product 1

HCID 14988296HCID 14988296, compound

Procedure

To a cold solution of 3-cyanomethyl-1H-indole (25 g) in 200 ml dimethylformamide (DMF), was added milled KOH (48 g) portionwise maintaining the temperature at 0° to 5° C.

Workup

  1. temperatureportionwise maintaining the temperature at 0° to 5° C.

Sources & evidence

ORD record
ord-8d8919e7b75444b188e424f2ce482674
Source dataset
uspto-grants-1991_08
Patent number
US05039811

Reaction notes

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