2-Methyl-1H-indol-1-amine → N-(3-Fluoro-4-pyridinyl)-2-methyl-1H-indol-1-amine

HRID 2248482Notes

Reaction equation

HRID 2248482 reaction equation
[CH3:1][C:2]1[N:3]([NH2:11])[C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.Cl.Cl[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[F:20]>CN1CCCC1=O>[F:20][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:14]=1[NH:11][N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[C:2]1[CH3:1]

Participants

4

Reactant 2

HCID 124272912-Methyl-1H-indol-1-amineHCID 193602344-Chloro-3-fluoropyridine hydrochloride

Product 1

HCID 14988279N-(3-Fluoro-4-pyridinyl)-2-methyl-1H-indol-1-amine

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound was prepared from 2-methyl-1H-indol-1-amine and 4-chloro-3-fluoropyridine hydrochloride in 1-methyl-2-pyrrolidone for 1 hour in substantially the same manner as in Example 1, m.p. 157°-158° C.

Sources & evidence

ORD record
ord-b998a7cb9d344ea7b76e211a4322dc7e
Source dataset
uspto-grants-1991_08
Patent number
US05039811

Reaction notes

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