3-Aminobenzoic Acid → HCID 53962591, compound

HRID 2248508Notes

Reaction equation

HRID 2248508 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([OH:22])=[O:21]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([OH:22])=[O:21])=[O:15])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 5458485-(((Tert-butoxy)carbonyl)amino)pentanoic acid

Product 1

HCID 53962591HCID 53962591, compound

Procedure

5-[1-(t-Butoxy)formamido]valeric acid is coupled with m-aminobenzoic acid to give m-[5-(1-t-butoxyformamido)valeramido]benzoic acid, m.p. 188° C., and the latter is reacted with 3-amino-3-phenylpropionic acid benzyl ester p-toluenesulphonate to give DL-N-[m-[5-(1-t-butoxyformamido)valeramido]benzoyl]-3-phenyl-β-alanine benzyl ester, MS: 574 (17, M+H).

Sources & evidence

ORD record
ord-28a7302f45174a3c83169d137bc80712
Source dataset
uspto-grants-1991_08
Patent number
US05039805

Reaction notes

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