Oxalyl chloride → HCID 19762439, compound

HRID 2248896Notes

Reaction equation

HRID 2248896 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1.C(Cl)(=O)C([Cl:25])=O>CN(C)C=O.C(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([Cl:25])=[O:18])=[CH:15][CH:14]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 98385524-(quinolin-2-ylmethoxy)benzoic Acid

Product 1

HCID 19762439HCID 19762439, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

1.28 g of 4-(quinolin-2-ylmethyloxy)benzoic acid, in 4.6 ml of oxalyl chloride and 3 drops of dimethylformamide are combined in 50 ml of methylene chloride. The mixture is refluxed for 30 minutes and then concentrated in vacuo to give 4-(quinolin-2-ylmethyloxy)benzoyl chloride

Workup

  1. temperatureThe mixture is refluxed for 30 minutes
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e7be43587bed4b149f5fca7de0db97ae
Source dataset
uspto-grants-1991_08
Patent number
US05041453

Reaction notes

Loading…