反应详情

(2-Methylphenoxymethyl)oxirane, 4.1 g., (0.025 mole) and 5.4 g. (0.025 mole) of 5-methoxy-α,α-dimethyl-1H-indol-3-yl-ethaneamine were mixed and heated at 130° for 2 hrs. The mixture was allowed to cool, but while still warm was dissolved in 60 ml. of acetonitrile and acidified with ethanolic 5 N HCl to pH 2. Th product crystallized as the hydrochloride salt, yield 8.3 g.; recrystallized from isopropanol/methanol, yield 7.4 g., m.p. 201.0°-203.0°.

1. temperatureheated at 130° for 2 hrs
2. temperatureto cool
3. temperaturewhile still warm
4. dissolutionwas dissolved in 60 ml
5. customTh product crystallized as the hydrochloride salt, yield 8.3 g
6. customrecrystallized from isopropanol/methanol, yield 7.4 g