HCID 15162481, compound → HCID 15162482, compound

HRID 2249030Notes

Reaction equation

HRID 2249030 reaction equation
[F:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[C:5]([Cl:10])=[C:4]([F:11])[C:3]=1[N+:12]([O-])=O>[Pd].C(O)(C)C>[F:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[C:5]([Cl:10])=[C:4]([F:11])[C:3]=1[NH2:12]

Participants

4

Reactant 1

HCID 15162481HCID 15162481, compound

Product 1

HCID 15162482HCID 15162482, compoundYield 92.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

To a 45 mL Hastelloy "C" pressure reactor was added 4.5 g of 2,6-difluoro-3,4,5-trichloronitrobenzene, 0.91 g of 10 percent palladium on charcoal and 25 mL of iso-propyl alcohol. The reactor was purged with nitrogen, sealed and pressurized to 130 psig with hydrogen. After stirring at ambient temperature for 5 hrs, the reactor was vented. The catalyst was removed by filtration and the solvent was evaporated under reduced pressure to give 3.7 g of solid product having a mp 137°-140° C. The IR, Mass and NMR spectra were consistent with the structure.

Workup

  1. customThe reactor was purged with nitrogen
  2. customsealed
  3. customThe catalyst was removed by filtration
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d0bdab52a5c64c36a78cf2039dcc04fd
Source dataset
uspto-grants-1991_08
Patent number
US05041674

Reaction notes

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