4-Methylmorpholine → HCID 19825692, compound

HRID 2249157Notes

Reaction equation

HRID 2249157 reaction equation
[O:1]=[C:2]([CH3:10])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=O.[CH3:11]N1CCOCC1.Cl[C:19]([O:21][CH2:22][CH:23]([CH3:25])C)=[O:20]>ClCCl>[CH3:11][CH:22]([O:21][C:19]([O:9][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2](=[O:1])[CH3:10])=[O:20])[CH2:23][CH3:25]

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 988106-Oxoheptanoic acid

Product 1

HCID 19825692HCID 19825692, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

11.2 g (0.07 mole) of 6-ketoheptanoic acid was dissolved in 100 ml of dichloromethane and 10 g of N-methylmorpholine was added. The reaction mixture was cooled in an ice bath, stirred and kept under a nitrogen atmosphere. 11.6 g (0.085 mole) of isobutyl chloroformate dissolved in 25 ml of dichloromethane was slowly added over a period of 15 minutes. The reaction mixture was allowed to proceed for one hour. The reaction mixture was evaporated to an oily solid and used in subsequent reactions.

Workup

  1. temperatureThe reaction mixture was cooled in an ice bath
  2. additionwas slowly added over a period of 15 minutes
  3. customThe reaction mixture was evaporated to an oily solid and used in subsequent reactions

Sources & evidence

ORD record
ord-fec40fe7435a4d6b914b5b113ec22024
Source dataset
uspto-grants-1991_08
Patent number
US05043340

Reaction notes

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