反应详情

To a solution of 271 mg (6.78 mmol) of sodium hydride contained at 60% in mineral oil in dry dimethylformamide (25 ml) was added 1.00 g (4.52 mmol) of 4-bromo-2-chlorobenzyl alcohol in an atmosphere of argon, and the mixture was allowed to react at 40°-50° C. for 30 min. Then, 1.54 g (5.42 mmol) of 4-bromo-2-chlorobenzyl bromide was added, and the mixture was reacted at room temperature for 18 hours. To the reaction mixture at 0° C. was added a saturated aqueous solution of ammonium chloride followed by extraction with ethyl acetate. The organic layer was washed with water and then concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography for separation and purification. Elution with ethyl acetate-hexane (1:4) yielded 1.69 g (3.97 mmol) of bis(4-bromo-2-chlorobenzyl) ether.

1. customto react at 40°-50° C. for 30 min
2. customthe mixture was reacted at room temperature for 18 hours
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed with water
5. concentrationconcentrated under reduced pressure
6. customThe residue thus obtained
7. customwas subjected to silica gel column chromatography for separation and purification
8. washElution with ethyl acetate-hexane (1:4)