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HRID2249341

反应详情

EQUATION

反应方程式

HRID 2249341 的结构方程式

REACTANTS

反应物

3
结构：CC(C)N=C=NC(C)C
HCID12734

Diisopropylcarbodiimide

C7H14N2

结构：CCC(C)(C)CCO
HCID4220190

3,3-dimethylpentan-1-ol

C7H16O

结构：CC1(C)CC(=O)CC(C)(C(=O)O)C1
HCID24975144

1,3,3-Trimethyl-5-oxocyclohexane-1-carboxylic acid

C10H16O3

PRODUCTS

生成物

1
结构：CC(C)(C)CCOC(=O)C1(C)CC(=O)CC(C)(C)C1
HCID22175123

未命名化合物

收率 56.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

1,5,5-trimethyl-3-oxo-1-cyclohexylcarboxylic acid (3.0 g) (M. S. Ziegler and R. M. Herbst, J. Org. Chem. 1951, 16, 920) was treated with 3,3-dimethylpentanol (1.84 g), DMAP (2.21 g) and 1,3-diisopropylcarbodiimide (2.17 g) in CH2Cl2 (80 mL) under standard coupling conditions to give 2.41 g (55% yield) of 3-(3,3-dimethylbutoxycarbonyl)-3,5,5-trimethylcyclohexanone. Mass spectrum (EI) indicated parent ion at m/e 268.