2-Methoxyethylamine → HCID 135856767, compound

HRID 2249454Notes

Reaction equation

HRID 2249454 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH3:27])[N:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:16]2[N:15]=1)[CH3:2].[CH3:28][O:29][CH2:30][CH2:31][NH2:32].COCCNS(C1C=CC=CC=1C1NC(=O)C2=C(C)N=C(CCC)N2N=1)(=O)=O>ClCCl.CO>[CH3:28][O:29][CH2:30][CH2:31][NH:32][S:10]([C:7]1[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[C:5]([C:14]2[NH:19][C:18](=[O:20])[C:17]3=[C:21]([CH3:27])[N:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:16]3[N:15]=2)[CH:6]=1)(=[O:12])=[O:11]

Participants

5

Reactant 3

HCID 80182-MethoxyethylamineHCID 1354301594-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzene-1-sulfonyl chlorideHCID 136355239HCID 136355239, compound

Product 1

HCID 135856767HCID 135856767, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

By the same method, starting with 1.23 g (3 mmol) of 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride and 680 mg (9 mmol) of 2-methoxyethylamine, 900 mg (67%) of N-(2-methoxyethyl)-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]triazin-2-yl)-4-benzenesulphonamide are obtained. Rf=0.25 (dichloromethane/methanol=95:5)

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-fb4c39d6254a4688b5e1e4880808339b
Source dataset
uspto-grants-2008_01
Patent number
US07314871B2

Reaction notes

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