HCID 11568876, compound → HCID 58670130, compound

HRID 2249505Notes

Reaction equation

HRID 2249505 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[N:13][C:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:15][CH:16]=2)[CH2:11][CH:10]([NH:24]C(=O)OCC2C=CC=CC=2)[C:9]1=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.CO.[Pd]>[NH2:24][CH:10]1[CH2:11][C:12]2[C:17](=[CH:16][CH:15]=[C:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:13]=2)[N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]1=[O:35]

Participants

5

Reactant 1

HCID 11568876HCID 11568876, compound

Product 1

HCID 58670130HCID 58670130, compoundYield 100%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2A (96 mg, 0.207 mmol) in THF (6 mL) and MeOH (6 mL) at RT was added palladium 5% wt on activated carbon (64 mg). The reaction mixture was stirred under a hydrogen balloon for 1 h. The reaction was filtered and the filtrate concentrated to give the title compound as a foam (68 mg, 100%). LC/MS (method A): retention time=2.65 min, (M+H)+=330.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-d923f2f706f5411b9c9a9345689e94e4
Source dataset
uspto-grants-2008_01
Patent number
US07314882B2

Reaction notes

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