反应详情

To a solution of (1-benzenesulfonyl-1H-pyrrol-3-yl)-acetic acid methyl ester (1.4 g, 5.01 mmol) in co-solvents of THF and water (1:1, 10 mL) was added LiOH hydrate (0.84 g, 20 mmol). The mixture was stirred at room temperature for 45 minutes and diluted with 50 mL of water. The resulting aqueous solution was washed once with EtOAc, acidified with 6N HCl, and extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated to a sticky yellow oil (1.33 g, 100%). The crude product was used directly. MS (ES+): m/e=266.1 (M+H); LC/Method A/3.08 min.

1. washThe resulting aqueous solution was washed once with EtOAc
2. extractionextracted with EtOAc
3. dry with materialThe combined organic layers were dried over MgSO4
4. concentrationconcentrated to a sticky yellow oil (1.33 g, 100%)
5. customLC/Method A/3.08 min.