反应详情

11.52 grams of 2-chlorohexanoic acid methyl ester were heated with 8.52 grams of potassium cyanate and 7.85 grams of methanol in 70 ml of DMF. After a reaction time of 30 hours the reaction mixture was worked up as described in Example 1. There were obtained 9.53 grams (67%) of 2-methoxycarbonylaminohexanoic acid methyl ester with a purity of 99% (determined gas chromatographically).

1. customAfter a reaction time of 30 hours