Methanol → HCID 11356158, compound

HRID 224955Notes

Reaction equation

HRID 224955 reaction equation
[CH3:1][O:2][C:3](=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]Br.[O-:11][C:12]#[N:13].[K+].[CH3:15][OH:16]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:13][C:12]([O:16][CH3:15])=[O:11]

Participants

5

Reactant 3

HCID 887MethanolHCID 4170292Methyl 6-BromohexanoateHCID 11378442Potassium cyanate

Product 1

HCID 11356158HCID 11356158, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The reaction of 10.45 grams of 6-bromohexanoic acid methyl ester with 6.08 grams of potassium cyanate and 2.7 grams of methanol in 50 ml DMF following the procedure of Example 1 gave 7.82 grams (76.9%) of 6-methoxycarbonylaminohexanoic acid methyl ester having a boiling point of 104° C./0.0013 mbar.

Sources & evidence

ORD record
ord-d650cda4d36044df91bdf1a415ecc60b
Source dataset
uspto-grants-1980_11
Patent number
US04234744

Reaction notes

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