4-Aminotetrahydropyran → HCID 59639536, compound

HRID 2249832Notes

Reaction equation

HRID 2249832 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[NH2:31][CH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12]([NH:31][CH:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 59639608HCID 59639608, compound

Product 1

HCID 59639536HCID 59639536, compoundYield 90%

Procedure

Following the general procedure outlined in Example 126, the product of Example 121(150 mg, 0.35 mmol), and 4-aminotetrahydropyran (179 mg, 1.77 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 140 mg (90%). LC-MS: 445.4 (MH+, m/z), 2.27 (Rt, min).

Workup

  1. customto give the crude material, which
  2. customwas purified

Sources & evidence

ORD record
ord-51cd2975f7ea42f984090810e1b98527
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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