反应详情

温度

40 °C

A mixture of 5-chloromethyl-indole-1-carboxylic acid tert-butyl ester (0.82 g, 3.10 mmol, 1.0 eq.), cyclohexyl mercaptan (0.53 mL, 1.4 eq.) and K2CO3 (0.90 g, 2.0 eq.) in DMF (6 mL) was heated at 40° C. until reaction completed. The reaction mixture was cooled to room temperature, diluted with sat. NH4Cl and extracted with diethyl ether. The organic extracts were dried over MgSO4, filtered and concentrated. The resulting mixture was purified by chromatography (5% EtOAc/hexanes) to give 5-cyclohexylsulfanylmethyl-indole-1-carboxylic acid tert-butyl ester (0.79 g, 74%).

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted with diethyl ether
3. dry with materialThe organic extracts were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe resulting mixture was purified by chromatography (5% EtOAc/hexanes)