4-Aminotetrahydropyran → HCID 59639622, compound

HRID 2250075Notes

Reaction equation

HRID 2250075 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:14]2[N:15]=[C:16](S(C)(=O)=O)[N:17]=[C:18]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[CH3:26])[C:13]=2[CH:12]=[CH:11][C:10]1=[O:31].[NH2:32][CH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>C1COCC1>[O:36]1[CH2:37][CH2:38][CH:33]([NH:32][C:16]2[N:17]=[C:18]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[CH3:26])[C:13]3[CH:12]=[CH:11][C:10](=[O:31])[N:9]([C:3]4[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=4[F:8])[C:14]=3[N:15]=2)[CH2:34][CH2:35]1

Participants

4

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 596395548-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one

Product 1

HCID 59639622HCID 59639622, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 48 (200 mg, 0.45 mmol) and 4-aminotetra-hydropyran (102 mg, 1 mmol) were combined in THF (10 mL) and stirred under Ar at 23° for 18 h. The solvents were removed in vacuo, and the residue was flash chromatographed with 0-15% EtOAc/CH2Cl2 Recrystallization from CH2Cl2/hexane gave the title compound as a light-yellow crystalline solid. mp 231-232°, LC MS m/z=467 (MH+) Retention time=2.27 min.

Workup

  1. customThe solvents were removed in vacuo
  2. customchromatographed with 0-15% EtOAc/CH2Cl2 Recrystallization from CH2Cl2/hexane

Sources & evidence

ORD record
ord-92df5bc2fbdd4a5ea5388894e3459a3c
Source dataset
uspto-grants-2008_01
Patent number
US07314934B2

Reaction notes

Loading…