Hydrochloric Acid → HCID 178428716, compound

HRID 2250367Notes

Reaction equation

HRID 2250367 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH2:9][CH2:10][C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][CH:18]=[C:13]3[N:12]=2)[N:3]=1.[ClH:20]>ClCCl.C(OCC)C>[ClH:20].[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH2:9][CH2:10][C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][CH:18]=[C:13]3[N:12]=2)[N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178428715HCID 178428715, compound

Product 1

HCID 178428716HCID 178428716, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

31 mg of 2-[2-(2-Amino-4-methylpyridin-6-yl)ethyl]-3H-imidazo[4,5-b]pyridine (compound1) are dissolved in 16 ml of dichloromethane. Under ice-cooling, 61 μl of a solution of hydrochloric acid in diethylether (2M strength) are added. The mixture is evaporated to dryness and the residue lyophillized from 15 ml water to give 35 mg of the title compound as colorless lyophilisate. M.p. 136° C. MS: 254.2 (MH+), 528.8 (2MNa+).

Workup

  1. temperatureUnder ice-cooling
  2. customThe mixture is evaporated to dryness

Sources & evidence

ORD record
ord-ca0731923a1b457b930d8274dee852fa
Source dataset
uspto-grants-2008_01
Patent number
US07317021B2

Reaction notes

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