反应详情

温度

-78 °C

tert-Butyl difluorothioacetate (100 mg) was dissolved in tetrahydrofuran (5 ml) and the solution was cooled to -78° C. Trimethylchlorosilane (151 μl) and lithium diisopropyl amide (327 μl, 2 M solution in heptane/tetrahydrofuran/ethyl-benzene). The solution was stirred for 1 hour at -78° C. then warmed to 25° C. The above product formed in a 65 percent yield as determined by 19F NMR Spectroscopy. 19F NMR (C6D6 vs C6F6, ppm) -104.2 (d, J=28 Hz), -92.6 (d, J=28 Hz).

1. temperaturethen warmed to 25° C
2. customThe above product formed in a 65 percent yield