反应详情

温度

110.5 °C

A mixture of 2-phenoxyethyl bromide (90.6 g, 0.45 mol), triphenylphosphine (119.2 g, 0.45 mol), and phenol (854 g) was heated to a melt and then stirred over a hot oil bath (107-114° C.) for ˜24 h. The reaction mixture was extracted with 6:1 heptane/EtOAc (3×2 L), 9:1 heptane/EtOAc (3×0.5 L), and heptane (300 mL) to give an oil that solidified. After dissolving the reaction mixture in DMSO, the mixture was warmed, treated with pyrrolidine (150 mL), and stirred over a hot oil bath (50-55° C.) for 1.5 h. The reaction mixture was cooled to room temperature, seeded for crystallization, and treated slowly and intermittently with increasing amounts of t-butyl methyl ether (TBME) until it was evident that crystallization was complete. The solid was filtered, washed with TBME and then with heptane, and vacuum dried to give 90.27 g of the desired product. The structure was confirmed by 1H NMR.

1. temperaturewas heated to a melt
2. extractionThe reaction mixture was extracted with 6:1 heptane/EtOAc (3×2 L), 9:1 heptane/EtOAc (3×0.5 L), and heptane (300 mL)
3. customto give an oil that solidified
4. temperaturethe mixture was warmed
5. stirringstirred over a hot oil bath (50-55° C.) for 1.5 h
6. temperatureThe reaction mixture was cooled to room temperature
7. customseeded for crystallization
8. additiontreated slowly and intermittently with increasing amounts of t-butyl methyl ether (TBME) until it
9. customwas evident that crystallization
10. filtrationThe solid was filtered
11. washwashed with TBME
12. dry with materialwith heptane, and vacuum dried