Lithium Hydroxide → HCID 69227321, compound

HRID 2250435Notes

Reaction equation

HRID 2250435 reaction equation
C[O:2][C:3]([C:5]1[N:13]([CH2:14][C:15]2[CH:19]=[C:18]([C:20]3[S:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[O:17][N:16]=2)[C:12]2[CH:11]=[CH:10][C:9](=[O:26])[NH:8][C:7]=2[CH:6]=1)=[O:4].[OH-].[Li+]>O1CCCC1.O>[Cl:25][C:22]1[S:21][C:20]([C:18]2[O:17][N:16]=[C:15]([CH2:14][N:13]3[C:12]4[CH:11]=[CH:10][C:9](=[O:26])[NH:8][C:7]=4[CH:6]=[C:5]3[C:3]([OH:4])=[O:2])[CH:19]=2)=[CH:24][CH:23]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 69227602HCID 69227602, compound

Product 1

HCID 69227321HCID 69227321, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 20 mg) 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid methyl ester and 1.9 mg lithium hydroxide in a mixture of 2 ml tetrahydrofuran and 1 mL water was stirred for 2 hours at room temperature. The solvent was removed under reduced pressure and the residue was coevaporated twice with toluene. The residue was directly subjected to the subsequent reaction without further purification.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customThe residue was directly subjected to the subsequent reaction without further purification

Sources & evidence

ORD record
ord-4adf40c99a16457a9e9c04279e92f02e
Source dataset
uspto-grants-2008_01
Patent number
US07317027B2

Reaction notes

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