Hydroxylamine → HCID 178510916, compound

HRID 2250465Notes

Reaction equation

HRID 2250465 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]#[N:11])=[CH:4][CH:3]=1.[OH:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[CH:9][C:10]([NH:13][OH:12])=[NH:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 342433-(4-Chlorophenyl)prop-2-enenitrile

Product 1

HCID 178510916HCID 178510916, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-(4-chloro-phenyl)-acrylonitrile (1.63 g, 10 mmol) and hydroxyamine (0.74 ml, 12 mmol) in ethanol (10 ml) was stirred at room temperature overnight. The solvent was evaporated, and the residue was purified by column chromatography (EtOAc:Hexane=1:3) to give 1.0 g (51%) of 3-(4-chloro-phenyl)-N-hydroxy-acrylamidine.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by column chromatography (EtOAc:Hexane=1:3)

Sources & evidence

ORD record
ord-f73876dd3cff47bbb2dd0e877d4a4cee
Source dataset
uspto-grants-2008_01
Patent number
US07317029B2

Reaction notes

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