Chlorosuccinimide → HCID 22139857, compound

HRID 2250514Notes

Reaction equation

HRID 2250514 reaction equation
[Cl:1][C:2]1[C:3]([NH:7][C:8]2[NH:12][C:11]3[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:10]=3[N:9]=2)=[CH:4][S:5][CH:6]=1.[Cl:19]N1C(=O)CCC1=O>C(O)(=O)C>[ClH:1].[Cl:19][C:4]1[S:5][CH:6]=[C:2]([Cl:1])[C:3]=1[NH:7][C:8]1[NH:12][C:11]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:10]=2[N:9]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 22139822HCID 22139822, compound

Product 1

HCID 22139857HCID 22139857, compoundYield 74.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To (4-chloro-thiophen-3-yl)-(5,6-difluoro-1H-benzoimidazol-2-yl)-amine (125 mg) in acetic acid (8 ml) a solution of N-chlorosuccinimide (59 mg) in acetic acid (2 ml) was added. Following the analogous description in example 54c) the desired product (58 mg) was obtained.

Sources & evidence

ORD record
ord-be4edbd377a64ea5a2bf8d9668f75616
Source dataset
uspto-grants-2008_01
Patent number
US07317033B2

Reaction notes

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