HCID 24824335, compound → HCID 19899911, compound

HRID 2250520Notes

Reaction equation

HRID 2250520 reaction equation
C[O:2][C:3](=[O:19])[CH:4]([C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=[CH:11][C:10]=1[F:18])C(OC)=O>Cl>[F:18][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]([N+:15]([O-:17])=[O:16])[C:9]=1[CH2:4][C:3]([OH:19])=[O:2]

Participants

3

Reactant 1

HCID 24824335HCID 24824335, compound

Product 1

HCID 19899911HCID 19899911, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-(2-Fluoro-6-nitro-phenyl)-malonic acid dimethyl ester (6.5 g, 23.98 mmol) was refluxed in 200 mL 6N hydrochloric acid for 24 hours. The solid was collected by suction filtration, and dried to give 3.3 g, 54% yield of the title compound.

Workup

  1. filtrationThe solid was collected by suction filtration
  2. customdried

Sources & evidence

ORD record
ord-6b0ef12fefc14dceb7776f77edad437a
Source dataset
uspto-grants-2008_01
Patent number
US07317037B2

Reaction notes

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