2-Methylpyrrolidine → 8-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

HRID 2251119Notes

Reaction equation

HRID 2251119 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[N:18]3[C:22]([N:23]=[C:24]4[CH2:30][CH2:29]CC[CH2:26][C:25]=24)=[CH:21][CH:20]=[N:19]3)=[CH:13][CH:12]=1.ClCCCOC1C=CC(C2N3C(=CC=N3)N=C3C=2CCC3)=CC=1.CC1CCCN1>>[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[N:18]3[C:22](=[CH:21][CH:20]=[N:19]3)[N:23]=[C:24]3[C:25]=2[CH2:26][CH2:29][CH2:30]3)=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 130032-MethylpyrrolidineHCID 1161113010-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indeneHCID 692558128-[4-(3-Chloro-propoxy)-phenyl]-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

Product 1

HCID 116752288-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

Procedure

Using the method described for the preparation of 10-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 8-[4-(3-chloro-propoxy)-phenyl]-6,7-dihydro-5H-1,4,8a-triaza-s-indacene and 2-methyl-pyrrolidine provided the title compound.

Sources & evidence

ORD record
ord-615ae4b9557f4c34bf735e024931c905
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

Loading…