2-Methylpyrrolidine → 8-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

HRID 2251136Notes

Reaction equation

HRID 2251136 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:23]3[C:19](=[CH:20][CH:21]=[N:22]3)[N:18]=[C:17]3[C:13]=2[CH2:14][O:15][CH2:16]3)=[CH:8][CH:7]=1.[CH3:24][CH:25]1[CH2:29][CH2:28][CH2:27][NH:26]1>>[CH3:24][CH:25]1[CH2:29][CH2:28][CH2:27][N:26]1[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:23]3[C:19](=[CH:20][CH:21]=[N:22]3)[N:18]=[C:17]3[C:13]=2[CH2:14][O:15][CH2:16]3)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 130032-MethylpyrrolidineHCID 585877208-[4-(3-Chloro-propoxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

Product 1

HCID 115744148-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-5H,7H-6-oxa-1,4,8a-triaza-s-indacene

Procedure

Using the method described for the preparation of 10-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[t]indene, the reaction of 8-[4-(3-Chloro-propoxy)-phenyl]-5H,7H-6-oxa-1,4,8a-triaza-s-indacene and 2-methyl-pyrrolidine provided compound.

Sources & evidence

ORD record
ord-4db1fa0bbf6f43189c07de5f85ca1d51
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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