Piperazine → 1-[4-(Ethylsulphonyl)-2-fluorophenyl]piperazine

HRID 2251253Notes

Reaction equation

HRID 2251253 reaction equation
[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9](F)=[C:8]([F:13])[CH:7]=1)(=[O:5])=[O:4])[CH3:2].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>CN(C)C(=O)C>[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[C:8]([F:13])[CH:7]=1)(=[O:5])=[O:4])[CH3:2]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 265973661,2-Difluoro-4-ethylsulfonylbenzene

Product 1

HCID 265975871-[4-(Ethylsulphonyl)-2-fluorophenyl]piperazine

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
80 °C

Procedure

To 2.0 mmol 4-ethanesulfonyl-1,2-difluoro-benzene in 5 ml N,N-dimethylacetamide was added 5.6 mmol piperazine and the mixture was heated at 80° C. for 45 min. The mixture was then concentrated in vacuo to afford the title compound. MS (m/e): 273.0 (M+H+, 100%)

Workup

  1. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-b45bca94393f460797410a3376bce033
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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