Piperazine → HCID 69036721, compound

HRID 2251260Notes

Reaction equation

HRID 2251260 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])(=[O:10])=[O:9])=[CH:4][C:3]=1[F:17].[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>CN(C)C(=O)C>[F:17][C:3]1[CH:4]=[C:5]([S:8]([CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])(=[O:10])=[O:9])[CH:6]=[CH:7][C:2]=1[N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 69037313HCID 69037313, compound

Product 1

HCID 69036721HCID 69036721, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
80 °C

Procedure

To 0.5 mmol 1,2-difluoro-4-(3,3,3-trifluoro-propane-1-sulfonyl)-benzene in 5 ml N,N-dimethylacetamide was added 1.5 mmol piperazine, and the mixture was heated at 80° C. for 90 min. The mixture was then concentrated in vacuo, and the residue was chromatographed on silica gel (eluant: methanol/dichloromethane gradient) to afford the title compound. MS (m/e): 341.2 (M+H+, 100%)

Workup

  1. concentrationThe mixture was then concentrated in vacuo
  2. customthe residue was chromatographed on silica gel (eluant: methanol/dichloromethane gradient)

Sources & evidence

ORD record
ord-b4ee92edd3e845848e9b9538ff73a47a
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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