Trifluoroacetic acid → HCID 69039149, compound

HRID 2251283Notes

Reaction equation

HRID 2251283 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[N:16][CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[N:11]1([C:14]2[N:15]=[N:16][CH:17]=[C:18]([C:20]([F:23])([F:21])[F:22])[CH:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69038776HCID 69038776, compound

Product 1

HCID 69039149HCID 69039149, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(5-Trifluoromethyl-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester (45 mg) was dissolved in dichloromethane (0.5 mL), and trifluoroacetic acid was added (0.5 mL). The reaction mixture was stirred for 30 minutes before being concentrated in vacuo to afford the crude title compound which was used directly in the next step without further purification or analysis.

Workup

  1. concentrationbefore being concentrated in vacuo

Sources & evidence

ORD record
ord-28c111e68f6f4b4d821fe8ba6f3850cc
Source dataset
uspto-grants-2008_01
Patent number
US07319099B2

Reaction notes

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