Methanol → 1-Bromo-4-(1,1-dimethoxyethyl)benzene

HRID 2251752Notes

Reaction equation

HRID 2251752 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][CH:5]=1)=[O:3].[CH:11](OC)(OC)[O:12]C.[CH3:18]O>>[Br:10][C:7]1[CH:8]=[CH:9][C:4]([C:2]([O:12][CH3:11])([O:3][CH3:18])[CH3:1])=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 7466p-BromoacetophenoneHCID 9005Trimethyl orthoformate

Product 1

HCID 109117821-Bromo-4-(1,1-dimethoxyethyl)benzene

Procedure

A mixture of 2 g (0.01 mole) of 4-bromoacetophenone, 5.6 ml of trimethyl orthoformate, 5.6 ml of methanol and 0.67 g of Amberlite® IR 120 is refluxed for three hours. After cooling, it is filtered through, Celite® and the filtered solution is evaporated. 2.4 g of the title product are obtained as an oil.

Workup

  1. temperatureis refluxed for three hours
  2. temperatureAfter cooling
  3. filtrationit is filtered through, Celite®
  4. customthe filtered solution is evaporated

Sources & evidence

ORD record
ord-cf6ace7e8a934a98bcd149c796d6c813
Source dataset
uspto-grants-2008_01
Patent number
US07320982B2

Reaction notes

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