反应详情

A solution of 1-bromopropylbenzene (51.7 g.) in ether (234 ml.) is added dropwise over a 2-hour period to a refluxing mixture of magnesium (7.32 g.) in ether (78 ml.). The reaction mixture is refluxed for 30 minutes longer and then a solution of 3-methoxy-acetophenone (46.3 g.) in ether (78 ml.) is added dropwise and heated to reflux for 1.5 hours. The reaction is quenched by addition of saturated ammonium chloride (234 ml.), the ether layer is separated and the aqueous phase extracted with ether (3×200 ml.). The combined ether extracts are dried over magnesium sulfate and concentrated under vacuum to yield an oil. The oil is hydrogenated in a mixture containing ethanol (600 ml.), concentrated hydrochloric acid (4 ml.) and 5% palladium-on-carbon (10 g.). The catalyst is filtered off and the ethanol removed under vacuum. The residue is distilled under vacuum yielding 2-(3-methoxyphenyl)-5-phenylpentane.

1. temperatureThe reaction mixture is refluxed for 30 minutes longer
2. temperatureheated
3. temperatureto reflux for 1.5 hours
4. customThe reaction is quenched by addition of saturated ammonium chloride (234 ml.)
5. customthe ether layer is separated
6. extractionthe aqueous phase extracted with ether (3×200 ml.)
7. dry with materialThe combined ether extracts are dried over magnesium sulfate
8. concentrationconcentrated under vacuum
9. customto yield an oil
10. filtrationThe catalyst is filtered off
11. customthe ethanol removed under vacuum
12. distillationThe residue is distilled under vacuum