Trifluoroacetic acid → HCID 11166799, compound

HRID 2251849Notes

Reaction equation

HRID 2251849 reaction equation
C(OC([N:8]1[CH2:17][C:16]([CH3:19])([CH3:18])[C:15]2[C:10](=[CH:11][C:12]([N:20]3[CH2:28][C:27]4[C:22](=[C:23]([NH:29][CH2:30][C:31]5[CH:32]=[C:33]6[C:38](=[CH:39][CH:40]=5)[N:37]=[CH:36][CH:35]=[CH:34]6)[CH:24]=[CH:25][CH:26]=4)[C:21]3=[O:41])=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:18][C:16]1([CH3:19])[C:15]2[C:10](=[CH:11][C:12]([N:20]3[CH2:28][C:27]4[C:22](=[C:23]([NH:29][CH2:30][C:31]5[CH:32]=[C:33]6[C:38](=[CH:39][CH:40]=5)[N:37]=[CH:36][CH:35]=[CH:34]6)[CH:24]=[CH:25][CH:26]=4)[C:21]3=[O:41])=[CH:13][CH:14]=2)[CH2:9][NH:8][CH2:17]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11272796HCID 11272796, compound

Product 1

HCID 11166799HCID 11166799, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by treatment of 4,4-dimethyl-7-{1-oxo-7-[(quinolin-6-ylmethyl)-amino]-1,3-dihydro-isoindol-2-yl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (Example 3) with TFA in CH2Cl2. MS (m/z)=449.0 (M+H)+ Calc'd for C29H28N4O: 448.5.

Sources & evidence

ORD record
ord-ccea9957855845ccae783001d515615f
Source dataset
uspto-grants-2008_01
Patent number
US07320992B2

Reaction notes

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