反应详情

Tosyl chloride (9.8 g., 51 mM) is added to a solution of 3-(3-benzyloxyphenyl)-1-butanol (12.8 g., 50 mM) in pyridine (90 ml.) at -45° C. The reaction mixture is held at -35° C. for 18 hours and is then diluted with cold 2 N hydrochloric acid (1500 ml.) and extracted with ether (5×250 ml.). The combined extracts are washed with saturated sodium chloride solution (4×250 ml.) and then dried (Na2SO4). Concentration of the dried extract affords the product as an oil. It is crystallized by treatment with ether-hexane.

1. extractionextracted with ether (5×250 ml.)
2. washThe combined extracts are washed with saturated sodium chloride solution (4×250 ml.)
3. dry with materialdried (Na2SO4)
4. extractionConcentration of the dried extract