HCID 9828562, compound → HCID 9828561, compound

HRID 2251910Notes

Reaction equation

HRID 2251910 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][O:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[N:7]([CH2:16][C@H:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([N:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=3)[C:6]=2[CH:33]=1.[ClH:34].CC(O)C>CC(O)C>[ClH:1].[ClH:34].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][O:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[N:7]([CH2:16][C@H:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][CH2:23][C:24]3[CH:25]=[CH:26][C:27]([N:30]([CH3:32])[CH3:31])=[CH:28][CH:29]=3)[C:6]=2[CH:33]=1

Participants

4

Reactant 2

HCID 9828562HCID 9828562, compoundHCID 21912024Isopropanol hydrochloride

Product 1

HCID 9828561HCID 9828561, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

(R)-3-Chloro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (10.6 g, 22.9 mmol) was dissolved in 2-propanol (100 ml). 4 M hydrogen chloride/2-propanol (22.9 ml) was added to the obtained solution. The solvent was evaporated under reduced pressure, and 4 M hydrogen chloride/2-propanol (11.5 ml) was added to the residue. The solvent was evaporated under reduced pressure to obtain the title compound in the form of a light yellow solid (12.9 g, 100%).

Workup

  1. customThe solvent was evaporated under reduced pressure, and 4 M hydrogen chloride/2-propanol (11.5 ml)
  2. additionwas added to the residue
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-6dcbeab5fd76410d9ddb9fb79adfd0d6
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

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