Oxalyl chloride → HCID 54355152, compound

HRID 2251922Notes

Reaction equation

HRID 2251922 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.C(Cl)(=O)C(Cl)=O.Cl.[CH:19]1[C:29]2[CH2:28][CH2:27][C:26]3[CH:30]=[CH:31][CH:32]=[CH:33][C:25]=3[N:24]([C:34]([NH:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][NH2:43])=[O:35])[C:23]=2[CH:22]=[CH:21][CH:20]=1>>[CH:19]1[C:29]2[CH2:28][CH2:27][C:26]3[CH:30]=[CH:31][CH:32]=[CH:33][C:25]=3[N:24]([C:34]([NH:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][NH:43][C:9](=[O:11])[CH:8]=[CH:7][C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[O:35])[C:23]=2[CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 65578Oxalyl chlorideHCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 69306792HCID 69306792, compound

Product 1

HCID 54355152HCID 54355152, compound

Procedure

Batch size: 2.2 g (14.8 mmol) 3-(3-pyridyl)-acrylic acid, 2.5 g (19.7 mmol) oxalyl chloride, 4.5 g (44.5 mmol) TEA and 5.0 g (13.4 mmol) 6-(10,11-dihydro-dibenzo[b,f]azepin-5-yl-carbonylamino)-hexylamine hydrochloride.

Sources & evidence

ORD record
ord-f5de9445a6af433e8e76f5ac691a1937
Source dataset
uspto-grants-2008_01
Patent number
US07320993B1

Reaction notes

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