1,2-Dichloroethane → HCID 53741205, compound

HRID 2251929Notes

Reaction equation

HRID 2251929 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl.Cl.[C:27]1([CH:33]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:34]([NH:36][CH2:37][CH2:38][CH2:39][CH2:40][NH2:41])=[O:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:27]1([CH:33]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:34]([NH:36][CH2:37][CH2:38][CH2:39][CH2:40][NH:41][C:9](=[O:11])[CH:8]=[CH:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[O:35])[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 17940766HCID 17940766, compound

Product 1

HCID 53741205HCID 53741205, compound

Procedure

Batch size: 2.0 g (13.4 mmol) 3-(3-pyridyl)-acrylic acid, 3.0 g (29.6 mmol) TEA, 2.4 g (15.6 mmol) 88% HOBT, 3.0 g (15.6 mmol) EDC and 4.0 g (13.4 mmol) 4-diphenylacetylamino-butylamine hydrochloride.

Sources & evidence

ORD record
ord-965342c786364787b0f0c7d89d325557
Source dataset
uspto-grants-2008_01
Patent number
US07320993B1

Reaction notes

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